Candidature post-doc pour appel d’offre FRM et EMBO / Application for a FRM and EMBO post-doctoral fellowship
Team Autophagy, membrane dynamics, stress, and cancer, INSERM U1151-CNRS UMR8253, Institut Necker-Enfants Malades, Université Paris Descartes-Sorbonne Paris
Application deadline: April 15, 2019
Descriptive of position
We are looking for a candidate to explore Ferritinophagy and Ferroptosis in cancer stem cells (CSC). The successful candidate will apply for a post-doctoral fellowship at the Fondation Recherche Médicale (October 2019) and at EMBO (evaluation committee in May 2019).
The aim of proposed research is to determine the role of iron homeostasis in the maintenance and emergence of cancer stem cells (CSCs). We believe that targeting iron metabolism in CSCs is a promising new approach to cancer therapy. The project is funded by INSERM and « la ligue contre le cancer » hold by Dr. Ahmed Hamaï. This project would answer the following purpose:
1. Identify the molecular mechanism involved in the degradation of ferritin, iron storage protein, by lysosome to bring iron necessary to cell.
2. Identify the steps of initiation and executor of ferroptosis.
To answer this purpose, we have stem-like cellular models and transgenic mice developing spontaneously mammary tumors where CSCs have been identified. For more detail do not hesitated to contact ahmed.hamai[at]inserm.fr.
We are looking for a highly talented and motivated PhD graduate in molecular & cellular biology, genetics, immunology, public health, or similar scientific fields with a strong quantitative background. A solid experience in cancer biology, immunofluorescence microscopy and viral transduction are appreciated. Training in a variety of cell death analysis will be provided.
The post-holder must be creative, have a good track record and be at ease working both independently and as part of a team.
The successful applicant will assist Dr. Hamaï in coordination, execution and valorization of scientific activities related to the project, as follows:
• Participate in the animation of the scientific life of the team
• Plan, conduct and evaluate actions in adherence with project milestones and deliverables
• Collaborate to data analysis and interpretation in compliance with standards of scientific integrity
• Provide scientific/technical updating related to the area of expertise
• Participate in the supervision of PhD students working on the project
This position will be based in Paris (France), at Institute Necker enfants Malades a very attractive young institute. The successful applicant will join a dynamic environment of researchers and teachers in public health.
Working as part of a young and motivated team in a scientifically stimulating surrounding.
Deadline for applications:
For full consideration, applications should be received by April 15, 2019. Evaluation of candidates will begin soon after this date and the succesful candidate will apply for a post-doctoral fellowship at the Fondation Recherche Médicale (October 2019) and at EMBO (evaluation committee in May 2019).
How to Apply:
Please send your electronic application to firstname.lastname@example.org
• Cover letter,
• A complete list of publications including original articles and conference abstracts
• At least one letter of recommendation with name and contact details of referee (name, relation to candidate, e-mail and contact details)
1. El Hout M, Dos Santos L, Hamaï A*, Mehrpour M. * A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells. Semin Cancer Biol. 2018 Dec;53:125-138. *Co-corresponding Authors
2. Mai TT*, Hamaï A*, Hienzsch A*, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nat Chem. 2017 Oct;9(10):1025-1033. *Co-first Authors
3. Hamaï A, Mehrpour M. Autophagy and iron homeostasis Med Sci. 2017 Mars 33, 3, 260-267.
4. Hamaï A, Cañeque T, Müller S, Mai TT, Hienzsch A, Ginestier C, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. An iron hand over cancer stem cells. Autophagy. 2017 Aug 3;13(8):1465-1466.
5. Dupont N, Leroy C, Hamaï A, Codogno P. Long-Lived Protein Degradation During Autophagy. Methods Enzymol. 2017;588:31-40.
6. Morel E, Mehrpour M, Botti J, Dupont N, Hamaï A, Nascimbeni AC, Codogno P. Autophagy: A Druggable Process. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:375-398.
7. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.
8. Yue W*, Hamaï A*, Tonelli G, Bauvy C, Nicolas V, Tharinger H, Codogno P, Mehrpour M. Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy 2013 (5):714-29. *Co-first Authors
9. Tuloup-Minguez V*, Hamaï A* , Greffard A, Nicolas V, Codogno P, Botti J. Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle. 2013 12 (20):3317-28. *Co-first Authors.
10. Hamaï A, Pignon P, Raimbaud I, Duperrier-Amouriaux K, Senellart H, Hiret S, Douillard J-Y, Bennouna J, Ayyoub M, Valmori D. Human TH17 cells specific for the tumor antigen MAGE-A3 convert into IFN-γ secreting as they differentiate into effectors in vivo. Cancer Res. 2012;72 (5):1059-63.
11. Hamaï A, Codogno P. New targets for acetylation in autophagy. Sci Signal. 2012; 5 (231):pe29.