8th Proteasome & Autophagy Congress
April 25 – 27, 2018
Clermont-Ferrand – France
The 8th Proteasome & Autophagy Congress (https://colloque.inra.fr/proteasome-autophagy) will cover up-to date knowledge on proteolytic systems (Ubiquitin Proteasome System and Autophagy) and their implication in different diseases.
Understanding the molecular processes that control the Ubiquitin Proteasome System and Autophagy is crucial for the development of future therapeutic strategies. The Scientific and Organizing Committees set up an attractive scientific program with outstanding international speakers that have contributed to the characterization of the UPS and Autophagy, and to the development of new major concepts in proteolysis. The congress provides an opportunity for scientists to improve the transfer of knowledge from basic to applied science and from group leaders to young investigators, and to open new space of interest and investigation for the near future.
The first session of the Congress will cover new insights on Proteasome structure and function. Recent studies have focused on substrate targeting mechanisms. A specific session will be dedicated to signaling pathways that control the fine-tuning of protein modifications by ubiquitin (ubiquitination and deubiquitination) and Ub-like proteins. All these modifications play a crucial role in a wide range of cellular processes (cancer, cell stress, signal transduction, etc.). Autophagy is interconnected with the UPS and plays also a major role in cell homeostasis (particularly for eliminating abnormal organelles, controlling energy balance and protein trafficking). These aspects will be covered in the last session.
The meeting will be held in Clermont-Ferrand, the capital of Auvergne, with its University, University Hospitals and Research Institutes such as the INRA, the French National Institute for Agricultural Research. Auvergne is a magnificent province of France, famous for its volcanoes such as the Puy de Dôme, its history, castles, romanesque churches and gastronomy.