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Paper: GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions Brun S, Bestion E, Raymond E, Bassissi F, Macek Jilkova Z, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A, Lalmanach G, Vanderlynden L, Legouffe R, Stauber J, Schubert T, Plach MG, Courcambeck J, Drouot C, Jacquemot G, Serdjebi…

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Paper: Macrophage autophagy protects against hepatocellular carcinogenesis in mice

Macrophage autophagy protects against hepatocellular carcinogenesis in mice Deust A, Chobert M-N, Demontant V, Gricourt G, Denaës T, Thiolat A, Ruiz I, Rodriguez C, Pawlotsky JM & Teixeira-Clerc F. Scientific Reports, 2021 Sept;11(1):18809. Pubmed PMID: 34552122. Contact:Fatima Teixeira-Clerc – CR Inserm – fatima.clerc@inserm.fr Link to the paper: https://www.nature.com/articles/s41598-021-98203-5 Abstract: Macrophage autophagy protects against hepatocellular carcinoma…

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CFATG10 Besançon/Dijon May 31st-June 2nd 2022

The CFATG Scientific Commitee and the local organization Committee from Besançon and Dijon formed by Aurélie Baguet (Inserm UMR1098 RIGHT, Besançon), Gilles Despouy (Inserm UMR1098 RIGHT, Besançon), Michaël Guittaut (Inserm UMR1098 RIGHT, Besançon), Jean-Baptiste Bizeau (INRAE, UMR1324 CSGA, Dijon), Marie-Agnès Bringer (INRAE, UMR1324 CSGA, Dijon), Elise Jacquin (Inserm U1231 Dijon, Université Paris-Saclay), Pierre Lapaquette (UMR…

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Paper: TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition Dinh E, Rival T, Carrier A, Asfogo N, Corti O, Melon C, Salin P, Lortet S & Kerkerian-Le Goff1 L. Cell Death & Disease, 2021 May; 12(5):460. Pubmed PMID: 33966044. Contact: Lydia Kerkerian-Le Goff, DR CNRS, 1Aix Marseille Univ, CNRS, IBDM, NeuroMarseille, Marseille, France. Link…

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Paper: Implication of a lysosomal antigen in the pathogenesis of lupus

Implication of a lysosomal antigen in the pathogenesis of lupus erythematosus Wilhelm, M., Bonam, S.R., Schall, N., Bendorius, M., Korganow, A.-A., Lumbroso C., Muller, S. J Autoimmun. 2021 Jun;120:102633. Pubmed PMID: 33932829 Contact: Prof. Sylviane Muller, CNRS UMR7242 Biotechnologie et signalisation cellulaire, Université de Strasbourg/ Institut du Médicament de Strasbourg (IMS); Institut de science et…

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Paper: DRP-1-dependent autophagy, heat stress and mitochondrial rebuilding

Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1–dependent process Yanfang Chen, Romane Leboutet, Céline Largeau, Siham Zentout, Christophe Lefebvre, Agnès Delahodde, Emmanuel Culetto, Renaud Legouis.J Cell Biol. 2021 Apr 5;220(4):e201909139. doi: 10.1083/jcb.201909139. Pubmed PMID: 33734301. Contact: renaud.legouis@i2bc.paris-saclay.fr Lien vers l’article/Link to the paper: https://rupress.org/jcb/article-abstract/220/4/e201909139/211895/Autophagy-facilitates-mitochondrial-rebuilding?redirectedFrom=fulltext Résumé de l’article: Un processus d’autophagie dépendant de…

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Team: Signaling and pathophysiology of heart failure and aging – April 2021

Team: Signaling and pathophysiology of heart failure and aging Team presentation Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), INSERM UMR1297, CHU Rangueil, 1 avenue du Pr Jean Poulhès, 31000 Toulouse, France website : www.i2mc.inserm.fr Team Leaders : Frank Lezoualc’h, DR INSERM, frank.lezoualch@inserm.fr Jeanne Mialet-Perez, CRCN INSERM, jeanne.perez@inserm.fr Team members : Caroline Conte, MCU Yannis Sainte-Marie,…

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Paper: BAG6, a new receptor for mitophagy?

BAG6 promotes PINK1 signaling pathway and is essential for mitophagy Romain Ragimbeau, Leila El Kebriti, Salwa Sebti, Elise Fourgous, Abdelhay Boulahtouf, Giuseppe Arena, Lucile Espert, Andrei Turtoi, Céline Gongora, Nadine Houédé, Sophie Pattingre. FASEB J. 2021 Feb;35(2):e21361. doi: 10.1096/fj.202000930R. Pubmed PMID: 33522017. Contact: sophie.pattingre@inserm.fr Lien vers l’article / Link to the paper: https://faseb-onlinelibrary-wiley-com.proxy.insermbiblio.inist.fr/doi/10.1096/fj.202000930R Résumé de…

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