Autophagy pathway and intracellular compartments dynamics – November 2019 CFATG
Autophagy pathway and intracellular compartments dynamics – November 2019

Team: Autophagy pathway and intracellular compartments dynamics

Institut Necker Enfants Malades
Cell Biology Department
INSERM U1151
156 rue de Vaugirard
75015 PARIS, France

Team presentation

Websites :
https://www.institut-necker-enfants-malades.fr/index.php?menu=team&rubric=teamtabs&idfac=morel
https://www.researchgate.net/lab/Etienne-Morel-Lab-autophagy-pathway-and-intracellular-membrane-dynamics-Etienne-Morel

Team leader : Etienne Morel, INSERM researcher, etienne.morel[at]inserm.fr

Team members, 2019 :

Joelle BOTTI, researcher/lecturer
Nicolas DUPONT, researcher/lecturer
Federica ROCCIO, PhD candidate
Asma BOUKHALFA, PhD candidate
Irene PILA-CASTELLANOS, PhD candidate
Clemence BOR, master student
Patrice CODOGNO, research director (DR.EX, INSERM), emeritus
Etienne MOREL, researcher (INSERM)

From left to right: Federica ROCCIO, Clemence BOR, Morgane DJEBAR, Karla ALVAREZ, Joelle BOTTI, Nicolas DUPONT, Diana MOLINO, Caterina MICELLI, Etienne MOREL, Asma BOUKHALFA, Irene PILA-CASTELLANOS

Keywords: autophagy and cellular stresses, intracelluar signalization, membrane dynamics and trafficking, primary cilium, mitochondria, endoplasmic reticulum, endosome, phosphoinositides, epithelial physiology, virale infection.

Research Topic:

Our project aims at investigating the cellular and molecular mechanisms that regulate autophagic pathway during stress response in cooperation with other endomembranes, in physiological and pathophysiological situations.
We study intracellular signaling and trafficking pathways (golden lines, figure below) that connect the autophagosome with endomembranes (primary cilium, mitochondria, endosomes, ER, etc.), or infectious agents, during integration of nutritional and mechanical stresses.

References (2016 – 2019):

1) The primary cilium protein folliculin is part of the autophagy signaling pathway to regulate epithelial cell size in response to fluid flow. Zemirli N, Boukhalfa A, Dupont N, Botti J, Codogno P, Morel E. Cell Stress. 2019 Feb 25;3(3):100-109. doi: 10.15698/cst2019.03.180.
2) Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline. Glatigny M, Moriceau S, Rivagorda M, Ramos-Brossier M, Nascimbeni AC, Lante F, Shanley MR, Boudarene N, Rousseaud A, Friedman AK, Settembre C, Kuperwasser N, Friedlander G, Buisson A, Morel E, Codogno P, Oury F. Curr Biol. 2019 Feb 4;29(3):435-448.e8.
3) Local detection of PtdIns3P at autophagosome biogenesis membrane platforms.
Nascimbeni AC, Codogno P, Morel E. Autophagy. 2017 Sep 2;13(9):1602-1612
4) ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis.Nascimbeni AC, Giordano F, Dupont N, Grasso D, Vaccaro MI, Codogno P, Morel E. EMBO J. 2017 Jul 14;36(14):2018-2033
5) Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow. Orhon I, Dupont N, Zaidan M, Boitez V, Burtin M, Schmitt A, Capiod T, Viau A, Beau I, Kuehn EW, Friedlander G, Terzi F, Codogno P. Nat Cell Biol. 2016 Jun;18(6):657-67

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