PhD position Institut Imagine (Paris, France) CFATG
PhD position Institut Imagine (Paris, France)

The role of protein and lipid uptake for nuclear hormone receptor and mTOR signaling pathways.

The Epithelial Biology and Disease laboratory headed by Matias Simons, Institut Imagine, 24 Boulevard du Montparnasse, Paris

Contract: 2 years with extension possibilities.
Start: April 1st 2019
Salary: Competitive, subject to skills and experience.

The Epithelial Biology and Disease laboratory headed by Matias Simons is looking for an enthusiastic postdoc to join our growing research group at the Imagine Institute for Genetic Diseases in Paris. The lab is generally interested in the molecular mechanisms underlying hereditary kidney and metabolic diseases. Most of these diseases are caused by single-gene defects and thereby offer unique opportunities to decipher fundamental regulatory pathways of human physiology and to develop targeted diagnostic and therapeutic options. We are particularly interested in diseases affecting renal proximal tubules, a nephron segment specialized in protein and lipid endocytosis. We combine human genetics with several experimental approaches, including fly and mouse genetics, cell culture, microscopy and biochemistry.

We offer an exciting project aimed at exploring the role of protein and lipid uptake for nuclear hormone receptor and mTOR signaling pathways. For this project, we invite applications from individuals with a strong background in molecular cell biology. Experience with Drosophila as well as CRISPR/Cas9-mediated genome editing is particularly desirable.

The Epithelial Biology and Disease laboratory belongs to the newly established Imagine Institute located in the heart of Paris ( Imagine is an interdisciplinary research center in molecular medicine in the Necker Enfants-Malades University Hospital campus. The focus of the institute is on rare genetic diseases, their biology and their life-long outcomes to address unmet basic needs. Thus, the successful applicant will be working in a stimulating work environment with scientific collaborations within the institute, across campus and worldwide.

The successful applicant will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion). We also invite applications from research-oriented MDs. Candidates are expected to be highly motivated and to work independently with a strong work ethic. As we are an international lab, proficiency in English language is a requirement. Applications including a cover letter, a detailed CV including a publication list and contacts of up to three referees should be sent as soon as possible and by January 31 the latest to matias.simons(at)

Key words: cell biology, metabolism, endocytosis, tissue homeostasis, nuclear hormone receptor, mTOR signaling, kidney disease, proximal tubules, CRISPR/Cas9, Drosophila

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