Post-Doc position in Autophagy, Microbes and Crohn’s disease (Clermont-Ferrand, France) CFATG
Post-Doc position in Autophagy, Microbes and Crohn’s disease (Clermont-Ferrand, France)

Post-doctoral position in Autophagy, Microbes and Crohn’s disease

Hang Nguyen’s group, Laboratory M2iSH (Microbe, intestine, inflammation and Susceptibility of the host), UMR1071 Inserm, USC-2018 Inra, Université Clermont Auvergne, Clermont-Ferrand, France (director of the research Unit: Prof. Nicolas Barnich)

Deadline: 31 November 2018. The selected candidates will be invited for a personal interview.
Starting date: As soon as possible (1st January 2019).
Website: click here

The project
The successful post-doctoral candidate will work under the supervision of Dr. Hang Nguyen (hang.nguyen@uca.fr). The project aims at understanding how a combination of genetic susceptibility (defective autophagy), microbial agents and environmental factors impact intestinal homeostasis, gut microbiota composition and mucosal immune responses, leading to chronic intestinal inflammation as observed in Crohn’s disease.

Qualifications
Post-doctoral candidates from French graduate schools will only be eligible after 2 years of postdoc in another country different from France.
We are looking for a highly motivated and enthusiastic candidate with the following qualifications:
A PhD degree in molecular biology, biochemistry, cellular biology, cellular microbiology or immunology.
Strong experiences in general cellular and molecular biology techniques.
Good publication record in one of the areas: gut ecosystem, immunology, cellular microbiology, gastroenterology, cell biology or molecular biology.
Experiences with animal studies and/or microbiota data analysis is an advantage.
Knowledge about autophagy and translation is an advantage.
Basic bioinformatic skills are an advantage.
Excellent written and oral communication skills in English.

The application should contain:
A motivation letter
Curriculum vitae (including education, research experience, publications, language skills and other relevant information for the position).
A copy of the PhD diploma.
Letters of recommendation
The application should be written in English and must be submitted electronically to: hang.nguyen@uca.fr.

Selected recent publications list:
1. Bretin A, Lucas C, Larabi A, Dalmasso G, Billard E, Barnich N, Bonnet R, Nguyen HTT*. AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation. Scientific Reports. 2018, 8(1):12301
2. Bretin A, Carrière J, Dalmasso G, Bergougnoux A, B’chir W, Maurin AC, Müller S, Seibold F, Barnich N, Bruhat A, Darfeuille-Michaud A, Nguyen HT*. Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy. 2016, 12(5):770-83.
3. Carrière J, Bretin A, Darfeuille-Michaud A, Barnich N, Nguyen HT*. Exosomes released from cells infected with Crohn’s disease-associated adherent-invasive Escherichia coli activate host innate immune responses and enhance bacterial intracellular replication. Inflammatory Bowel Disease. 2016, 22(3):516-28.
4. Nguyen HT*, Dalmasso G, Mueller S, Carriere J, Seibold F, Darfeuille-Michaud A. Crohn’s disease-associated adherent invasive Escherichia coli affect levels of microRNAs in intestinal epithelial cells to reduce autophagy. Gastroenterology. 2014, 146(2):508-19.
5. Nguyen HT*, Dalmasso G, Yan Y, Laroui H, Charania M, Ingersoll S, Ayyadurai S, Zhang Y, Sitaraman S, Merlin D. Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice. Lab Invest. 2012, 92(8):1203-12.
6. Martinez-Medina M, Denizot J, Dreux N, Robin F, Billard E, Bonnet R, Darfeuille-Michaud A, Barnich N. Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut. 2014, 63(1):116-24.
7. Nguyen HT#, Dalmasso G#, Ingersoll S, Ayyadurai S, Laroui H, Charania MA, Yan Y, Sitaraman SV, Merlin D. The PepT1/NOD2 signaling pathway plays a critical role in aggravation of induced colitis in mice. Gastroenterology. 2011, 141(4):1334-45.
8. Nguyen HT*, Dalmasso G, Torkvist L, Halfvarson J, Yan Y, Laroui H, Shmerling D, Tiziano, D’Amato M, Sitaraman SV, and Merlin D. CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice. Journal of Clinical Investigation. 2011, 121(5):1733-47.
9. Nguyen HT*, Dalmasso G, Yan Y, Laroui H, Dahan S, Mayer L, Sitaraman SV, Merlin D. MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation. J. Biol. Chem. 2010, 285(2):1479-89.
10. Nguyen HT*, Dalmasso G, Powell KR., Yan Y, Bhatt S, Kalman D, Sitaraman SV, Merlin D. Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response. Gastroenterology. 2009, 137(4):1435-47.

*Corresponding author; #equal contribution.

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