Post-doctoral position in the lipidic purge of pesticides: physiological mechanisms and evolutionary conservation
Research group of Frédéric Dalle at VAlMiS (Vin Aliment Microbiologie Stress) Unit, UMR PAM, Dijon, France.
Starting date: April 2019.
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A funded postdoctoral position is available from April 2019 at the VAlMiS (Vin Aliment Microbiologie Stress) Unit, UMR PAM, Dijon (Scientific leader of the project: Pr. Frederic Dalle). This one-year position is part of the collaborative ANR project ‘Lipidic Purge’ involving the VAlMiS unit and the UPR 9022 CNRS Strasbourg (Dr. Ferrandon Dominique, PI of the project).
The present project follows up a previous ANR grant (BEELOSS) in which the UPR 9022 made the major discovery that pesticide exposure favor intracellular parasitism by microsporidia and kills insects (Drosophila model) due to lipidic purge in enterocytes as a result of a competition for lipids between the parasite and pesticides. This project is focused on the lipidic purge as a resilience mechanism that represents a novel interaction of organisms with ingested xenobiotics, thus opening a novel and unexpected chapter in the field of detoxification. Based on preliminary data reporting lipidic purge in mammalian enterocytes exposed to pesticides, the post-doctoral fellow will study to which extent lipidicpurge is conserved in mammals. He will specify the cellular and molecular mechanisms of this enterocytic purge in in vitro models and will investigate the detrimental synergy possibly existing between pesticide exposure and intracellular paratism of other microorganism models. This project will be conducted in the « Pathophysiology of systemic infections » team of the VAlMiS Unit, UMR PAM, Dijon, France. This unit has expertise in host-pathogen interaction of microorganisms with gastro-intestinal mucosa. The University of Burgundy campus hosts expert teams in immunology, microbial pathogenesis, as well as cutting-edge technical platforms.
We are looking for a highly motivated investigator with a PhD in cellular and molecular biology/immunology of intestinal cells, a taste for multidisciplinary studies and an ability to work within a team. A solid expertise in cellular biology of the intestinal cells is expected. Experience in animal models and in microbiology will be appreciated. The post-doctoral position is for 1 year, renewable.
Interested candidates should send a letter summarizing research interests and career goals, CV with publication list and contact information for two academic references to: Pr. Frederic Dalle (E-mail: frederic.dalle[at]u-bourgogne.fr)Tweet