Doctoral position, Autophagy Infection Immunity Team, CIRI Lyon Inserm U1111

Contact

Aurore Rozières : aurore.rozieres@inserm.fr

Détails de l'offre

We propose a thesis project to study the influence of autophagy polymorphisms on Crohn’s disease.
Crohn’s disease is a chronic inflammatory bowel disease that affects more than one million patients in
Europe. This intestinal inflammation results from an inappropriate immune response to the gut
microbiota in a predisposed genetic context. Many genes have been identified as predisposing to
Crohn’s disease, several of which involve a major mechanism of the cell, autophagy. Autophagy is a
dynamic process that allows the degradation and recycling of damaged and obsolete elements of the
cell, and also controls infectious microbial agents. Despite important advances, the understanding of
the close link between autophagy dysfunction and Crohn’s disease remains largely unresolved, both at
the patient and cellular or molecular levels.
Thus, the objective of the thesis project is to evaluate the consequences of autophagy dysfunction,
resulting from the expression of autophagic variants in Crohn’s disease patients, on the quality of the
degradative activity of this process. To this end, cellular (patient lines and primary cells), imaging
(confocal), and molecular (proteomic) approaches will be used. This project is part of a collaborative
project, and will be carried out within the Autophagy Infection Immunity team specialized in the study
of autophagy in the context of infection and inflammation. The candidate will benefit from a high level
scientific (CIRI) and technical (SFR BioSciences) environment to carry out his/her project.
The candidate must have a solid knowledge of immunology and cell biology, and must show
enthusiasm, motivation, initiative and rigour.
Please send before 15 February 2023 :
– Letter of motivation with the names of two referees.
– Curriculum vitae
To Aurore Rozières: aurore.rozieres@inserm.fr
Selected publications
– M. Claviere, A. Lavedrine, G. Lamiral, M. Bonnet, P. Verlhac, D.S. Petkova, L. Espert, R. DuclauxLoras, J. Lucifora, M. Rivoire, G. Boschetti, S. Nancey, A. Rozières, C. Viret* and M. Faure*.
Measles Virus-Imposed Remodeling of the Autophagy Machinery Determines the Outcome of
Bacterial Coinfection. Autophagy, 2022, Aug 9;1-15.
– Servais L, Boschetti G, Meunier C, Gay C, Cotte E, François Y, Rozieres A, Fontaine J, Cuminal L,
Chauvenet M, Charlois AL, Isaac S, Traverse-Glehen A, Roblin X, Flourié B, Valette PJ, Nancey
S.Intestinal Conventional Ultrasonography, Contrast-Enhanced Ultrasonography and Magnetic
Resonance Enterography in Assessment of Crohn’s Disease Activity: A Comparison with Surgical
Histopathology Analysis. Dig Dis Sci. 2022 Jun;67(6):2492-2502.
– Moroso M, Verlhac P, Ferraris O, Rozières A, Carbonnelle C, Mély S, Endtz HP, Peyrefitte CN,
Paranhos-Baccalà G, Viret C, Faure M. Crimean-Congo hemorrhagic fever virus replication imposes
hyper-lipidation of MAP1LC3 in epithelial cells. Autophagy. 2020 Oct;16(10):1858-1870.
– Soufflet N, Boschetti G, Roblin X, Cuercq C, Williet N, Charlois AL, Duclaux-Loras R, Danion P, Mialon
A, Faure M, Paul S, Flourie B, Nancey S (2019). Concentrations of Ustekinumab During Induction
Therapy Associate With Remission in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol.
Mar; pii: S1542-3565(19)30248-4.

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