Keystone Symposia : Autophagy and Neurodegeneration: Mechanisms to Therapies -

Conference Program

The meeting will begin on Sunday, March 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, March 29 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, March 30 in order to fully experience the meeting.

SUNDAY, MARCH 26

16:00—20:00

Arrival and Registration

18:00—20:00

Welcome Mixer
No registration fees are used to fund alcohol served at this function.

MONDAY, MARCH 27

07:00—08:00

Breakfast

08:00—09:00

Welcome and Keynote Address
Registered attendees can view abstracts starting on 02/26/2023

Noboru Mizushima, University of Tokyo, Japan
Autophagy: Bridging Cell Biology and Biomedical Research

09:00—11:15

Autophagy Meets Translation
Registered attendees can view abstracts starting on 02/26/2023

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
Therapeutic Strategies using Autophagy in Neurodegeneration

Coffee Break

Ralph A. Nixon, New York University, Langone Medical Center, USA
Endosomal-Lysosomal Dysfunction as a Primary Catalyst and Therapeutic Target in Alzheimer’s Disease

Gilbert Di Paolo, Denali Therapeutics Inc., USA
Brain Delivery of Biotherapeutics Enhancing Lysosomal Function

Short Talk(s) Chosen from Abstracts

11:15—17:00

On Own for Lunch

11:15—13:00

Poster Setup

13:00—22:00

Poster Viewing

14:30—16:30

Workshop 1: Integrated Modulation of Organism Autophagy

Short Talks Chosen from Abstracts

16:30—17:00

Coffee Available

17:00—19:00

Autophagy: Cell Type and Location Matters
Registered attendees can view abstracts starting on 02/26/2023

Zhenyu Yue, Mount Sinai Medical Center, USA
The Landscape of Neuronal and Glial Autophagy

Sandra Maday, Perelman School of Medicine at the University of Pennsylvania, USA
Differential Regulation of Autophagy in Astrocytes and Neurons

David Sulzer, Columbia University, USA
Local Autophagy: Role of Autophagic Degradation in Synaptic Development

Short Talk Chosen from Abstracts

19:00—20:00

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00

Poster Session 1

TUESDAY, MARCH 28

07:00—08:00

Breakfast

08:00—11:00

Autophagy Malfunctioning in Disease: Step-Specific Failure

Ai Yamamoto, Columbia University, USA
Autophagic Cargo Selection in Aggregopathies

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Lysosomal Defects Behind Selective Autophagy Failure in Disease and Aging

Coffee Break

Ivan Dikic, Goethe University Medical School, Germany
Defects in ER-phagy and development of neuropathies

Karolina Milena Pircs, HCEMM-Semmelweis University and Lund University, Hungary
Direct Neural Conversion: New Possibilities to Model Late-Onset Neurodegenerative Diseases

Short Talk(s) Chosen from Abstracts

11:00—17:00 On Own for Lunch

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

16:30—17:00 Coffee Available

17:00—19:00

Autophagy and Neuronal Homeostasis in Aging

Yan Zhao, South China University of Technology, China
Autophagy Machinery in the Protection of Neuronal Homeostasis

Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Autophagy Energetics in Neurodegeneration

Malene Hansen, Buck Institute for Research on Aging, USA
Autophagy and its Role in Aging and Disease

Short Talk Chosen from Abstracts

19:00—20:00

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00

Poster Session 2

WEDNESDAY, MARCH 29

07:00—08:00

Breakfast

08:00—11:00

Targeting Components of the Autophagy-Endolysosomal System in Neurodegeneration

Hirokazu Arimoto, Tohoku University, Japan
Targeting Selective Autophagy by AUTAC Degraders

Nicholas T. Hertz, Mitokinin Inc., USA
Targeting Mitophagy in Neurodegeneration Diseases

Coffee Break

Judith Klumperman, University Medical Center Utrecht, Netherlands
VPS41; Role in Lysosomal Function, Composition and Parkinson’s Disease

Martin Kampmann, University of California, San Francisco, USA
Coupling of Neuronal Activity, Autophagy and Endolysosomal Trafficking to Neurodegeneration

Short Talk(s) Chosen from Abstracts

11:00—17:00

On Own for Lunch

14:30—16:30

Workshop 2: Monitoring Autophagy: Biomarkers and Disease-Precision « Omics »

Short Talks Chosen from Abstracts

16:30—17:00

Coffee Available

17:00—18:45

Approaches to Translation/Drug Discovery on Autophagy

Speaker to be Announced

Magdalene Moran, Caraway Therapeutics, USA
Targeting Lysosomal Ion Flux in Neurodegerative Disease

Speaker to be Announced

Short Talk Chosen from Abstracts

18:45—19:00

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

19:00—20:00

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

THURSDAY, MARCH 30

08:00—08:0

Departure