4 years postdoctoral position in Organelle Quality Control by Autophagy (Aarhus, Denmark)


Prof. Fulvio Reggiori Department of Biomedicine Aarhus Universdity Ole Worms Alle 4 8000 Aarhus C Denmark email: f.m.reggiori@aias.au.dk

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Autophagy is a catabolic process highly conserved among eukaryotes, which is involved in the degradation of long-lived proteins, aberrant complexes and aggregates, dysfunctional and superfluous organelles, and intracellular pathogens. Structures targeted to destruction, including intracellular organelles, are sequestered by double-membrane vesicles called autophagosomes and delivered to lysosomes for turnover. The central players of autophagy are the autophagy-related (ATG) proteins. Autophagy can be highly selective and target specific unwanted structures using the so-called selective autophagy receptors (SARs) and various adaptor proteins.

The overall aim of the project is to understand the relevance of autophagy, ATG proteins and SARs in the quality control of intracellular organelles such as the endoplasmic reticulum, mitochondria and peroxisomes. The overall idea is to identify how these players sense and then mediate the turnover of local dysfunctions in these organelles.

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