PhD students in Autophagy and Metabolic Signaling


Détails de l'offre

The Dengjel and De Virgilio Labs at the Dept. of Biology, University of Fribourg are interested in cellular
signal transduction and protein homeostasis. We characterize molecular pathways critical for cell
homeostasis, autophagy regulation and autophagosome biogenesis and employ mammalian and/or yeast
cell culture models, protein biochemistry, and mass spectrometry-based proteomics (1-4). Current projects
are supported by third-party grants from the Swiss National Science Foundation and private foundations.

We look for highly motivated PhD students with interests in the areas outlined above. Excellent
communication skills in English are of benefit.

We offer:
• a stimulating, interdisciplinary scientific environment
• state-of-the-art central facilities for proteomic, imaging and bioinformatic analyses
• a coordinated graduate program (
• a competitive Swiss salary

Fribourg and its University are located in the heart of Switzerland, 30 min from Bern and 50 min from
Lausanne. Research and life conditions are excellent. Major facilities are either on campus or available
through national networks. The Dengjel Lab is actively engaged in SKINTEGRITY.CH and Life Science
Switzerland (LS2).

The starting date for this position is July 1st, 2024 (or later). Interested candidates should send a SINGLE
PDF application including a CV, a brief statement of their research interests, a copy of their MSc diploma,
and names of three referees by email to:

(1) Zhou, J., et al. (2023). TBK1 phosphorylation activates LIR-dependent degradation of the inflammation
repressor TNIP1. J Cell Biol 222.
(2) Kaeser-Pebernard, S., et al. (2022). mTORC1 controls Golgi architecture and vesicle secretion by
phosphorylation of SCYL1. Nat Commun 13, 4685.
(3) Dokládal L., et al. (2021). Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms
of translational control. Mol Cell 81:1879-1889.e6.
(4) Hu Z, et al. (2019). Multilayered Control of Protein Turnover by TORC1 and Atg1. Cell Rep. 28:3486-


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