How long does it take to activate autophagy ?
In mammalian cells, there are three main types of autophagy: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). Although each type is morphologically distinct, all three result in the delivery of cargo to the lysosome for degradation and recycling. Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then directed to lysosomes and translocated directly across the lysosome membrane for degradation. During macroautophagy, autophagosomes deliver cytoplasmic constituents to endosomes or lysosomes, whereas during microautophagy, the lysosome directly “takes up” a portion of cytoplasm.