Autophagy and protein homeostasis

University of Fribourg
Biology Department,
Prof. J. Dengjel's lab
Chemin du musée 10
CH-1700 FRIBOURG
SUISSE
- FRIBOURG
Site web - stephanie.kaeser-pebernard@unifr.ch -

Principal investigator

Prof. Jörn Dengjel

From the left to the right. : D. Siva Sankar, J. Dengjel, C. Brumann, G. Lampo, M. Stumpe, S. Sander, I. Bayramoglou, M. Brunner, A. Leytens, S. Kaeser-Pebernard

Research themes

We use biochemical approaches based on quantitative mass spectrometry (MS)-based proteomics to study the molecular mechanisms involved in autophagy, its influence on the cellular microenvironment and its role in skin disorders.

Publications

 

 

Caligaris M, Nicastro R, Hu Z, Tripodi F, Hummel JE, Pillet B, Deprez MA, Winderickx J, Rospert S, Coccetti P, Dengjel J, De Virgilio C. Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation. Elife. 2023 Feb 7;12:e84319. doi: 10.7554/eLife.84319. PMID: 36749016

Zhou, J., Lander Rasmussen, N., Lauritz Olsvik, H., Akimov, V., Hu, Z., Evjen, G., Kaeser-Pebernard, S., Siva Sankar, D., Roubaty, C., Verlhac, P., van de Beck, N., Reggiori, F., Princely Abudu, Y., Blagoev, B., Lamark, T., Johansen, T., and Dengjel, J. (2022). TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1. J Cell Biol. 2023 Feb 6;222(2):e202108144. doi: 10.1083/jcb.202108144. Epub 2022 Dec 27. PMID: 36574265.

Kaeser-Pebernard, S., Vionnet, C., Mari, M., Sankar, D.S., Hu, Z., Roubaty, C., Martinez-Martinez, E., Zhao, H., Spuch-Calvar, M., Petri-Fink, A., Rainer, G., Steinberg, F., Reggiori, F., and Dengjel, J. (2022). mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1. Nat Commun 13, 4685.

Leytens, A., and Dengjel, J. (2022). DRAMing for autophagy. FEBS J 289, 3731-3734.

Siva Sankar, D., Hu, Z., and Dengjel, J. (2022). The complex interplay between ULK1 and protein phosphatases in autophagy regulation. Autophagy 18, 455-456.

Stekovic S, Hofer SJ, Tripolt N, Aon MA, Royer P, Pein L, Stadler JT, Pendl T, Prietl B, Url J, Schroeder S, Tadic J, Eisenberg T, Magnes C, Stumpe M, Zuegner E, Bordag N, Riedl R, Schmidt A, Kolesnik E, Verheyen N, Springer A, Madl T, Sinner F, de Cabo R, Kroemer G, Obermayer-Pietsch B, Dengjel J, Sourij H, Pieber TR, Madeo F.Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans. Cell Metab. 2019 Sep 3;30(3):462-476.e6. doi: 10.1016/j.cmet.2019.07.016. Epub 2019 Aug 27. PMID: 31471173

 

Composition de l'équipe

Prof. Jörn Dengjel, PhD : Professeur Ordinaire, chef de groupe
Stéphanie Kaeser-Pebernard, PhD: lab manager
Michael Stumpe: technicien de plateforme protéomique
Devanarayanan Siva Sankar: doctorant
Alexandre Leytens: doctorant
Mélanie Brunner: doctorant
Sibilla Sander: doctorante
Ibrahim Bayramoglou: doctorant
Carole Roubaty: laborantine
Christine Vionnet: laborantine
Christelle Brumann: étudiante Master