SIGNALPHAGY

Institut de Recherche sur le Cancer et le Vieillissement de Nice (IRCAN)
Institut de Recherche sur le Cancer et le Vieillissement de Nice (IRCAN)
Centre Antoine Lacassagne
Avenue de Valombrose
06107 Nice Cedex 02, France - Nice
Site web - mograbi@unice.fr -

Research themes

Since 2004, my research activity has been devoted to understand the tumor suppressive function of autophagy particularly in non-small cell lung cancer (NSCLC), which is the leading cause of cancer death worldwide. To succeed in this effort, I conduct a multidisciplinary program integrating basic, clinical, molecular, and genetics approaches. I recruited a postdoc (A Chargui now MCU, University of Tunis), two PhD students (E Corcelle now senior researcher Denmark, and A Belaid, post-doctoral fellow at Harvard Medical School USA) and five technicians/engineers (M Nebout, Djerbi N, P Ndiaye, N Durand, B Romeo).

A. Homeostasis and tumor suppression – Concept of Signalphagy

Specifically, our works describe an important discovery concerning the control of the RHOA pathway by autophagy.

B. Inhibition by pollutants / environmental carcinogens

Supported by ADEME, the Health and Environment Plan (ARS and DREAL), the PACA region and ANR, we provided the first evidence that: