Autophagy pathway and intracellular compartments dynamics
Institut Necker Enfants MaladesCell Biology Department
INSERM U1151
156 rue de Vaugirard
75015 PARIS, France - Paris
Site web - etienne.morel@inserm.fr -
Principal investigator
Etienne Morel
Research themes
Our project aims at investigating the cellular and molecular mechanisms that regulate autophagic pathway during stress response in cooperation with other endomembranes, in physiological and pathophysiological situations.
We study intracellular signaling and trafficking pathways (golden lines, figure below) that connect the autophagosome with endomembranes (primary cilium, mitochondria, endosomes, ER, etc.), or infectious agents, during integration of nutritional and mechanical stresses.
Descriptive figure
Publications
1) The primary cilium protein folliculin is part of the autophagy signaling pathway to regulate epithelial cell size in response to fluid flow. Zemirli N, Boukhalfa A, Dupont N, Botti J, Codogno P, Morel E. Cell Stress. 2019 Feb 25;3(3):100-109. doi: 10.15698/cst2019.03.180.
2) Autophagy Is Required for Memory Formation and Reverses Age-Related Memory. Decline. Glatigny M, Moriceau S, Rivagorda M, Ramos-Brossier M, Nascimbeni AC, Lante F, Shanley MR, Boudarene N, Rousseaud A, Friedman AK, Settembre C, Kuperwasser N, Friedlander G, Buisson A, Morel E, Codogno P, Oury F. Curr Biol. 2019 Feb 4;29(3):435-448.e8.
3) Local detection of PtdIns3P at autophagosome biogenesis membrane platforms.
Nascimbeni AC, Codogno P, Morel E. Autophagy. 2017 Sep 2;13(9):1602-1612
4) ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis. Nascimbeni AC, Giordano F, Dupont N, Grasso D, Vaccaro MI, Codogno P, Morel E. EMBO J. 2017 Jul 14;36(14):2018-2033
5) Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow. Orhon I, Dupont N, Zaidan M, Boitez V, Burtin M, Schmitt A, Capiod T, Viau A, Beau I, Kuehn EW, Friedlander G, Terzi F, Codogno P. Nat Cell Biol. 2016 Jun;18(6):657-67
Composition de l'équipe
Joelle BOTTI, enseignante-chercheuse
Nicolas DUPONT, enseignant-chercheur
Federica ROCCIO, doctorante
Asma BOUKHALFA, doctorante
Irene PILA-CASTELLANOS, doctorante
Clemence BOR, étudiante
Patrice CODOGNO, directeur de recherche (DR.EX, INSERM), emeritus
Etienne MOREL, chargé de recherche (INSERM)